Peyronie's Disease Treatment in Israel

Oral Medications
Oral medications that are used for the treatment of Peyronie’s Disease include the following:

• Vitamin E
  Vitamin E has been used to treat Peyronie’s Disease since 1945. It is a useful anti-oxidant and is also used in treating scars.
• Potaba
  Potassium para amino benzoate also known as Potaba may have effective results if used in large doses. This may however, cause intestinal illness.
• Colchicine
  Colchicine is widely used in treating gout. It helps in reducing inflammation and fights against the production of scar tissues.
• Tamoxifen
  Tamoxifen is a non-steroidal medication that is anti-estrogen. It is used in the treatment of a condition similar to Peyronie’s disease, known as desmoid tumors.
• Carnitine
  Carnitine is an antioxidant that aims to decrease inflammation and reduce abnormal healing of wound.

Penile Injections
Penile injections allow the direct appliance of drugs into the plaque and are effective when used in high doses. A local anesthesia may be administered before the injection is given to the patient. It is a minimally invasive method of treating Peyronie’s Disease. Patients who have other diseases or who are unwilling to undergo surgery may use penile injections.

• Verapamil
  Verapamil is administered as a direct injection that stops the production of scar tissue precursors. It is used in treating high blood pressure. The production of collagen is known to be stopped by using Verapamil. Studies show that Verapamil is successful in treating penile curvature and pain. Research is still ongoing on this drug.
• Collagenase
  Researchers are working on the effectiveness of Collagenase to disrupt formation of the plaque of Peyronie’s disease.
• Interferon Injections
  Interferon is a protein produced in the body. It is used in treating keloid scars and scleroderma.

Investigative Therapies
Therapies that are being researched for the treatment of Peyronie’s disease are:

• High-intensity Ultrasound
• Shock-wave treatment
• Hyperthermia
• Radiation therapy
• External penile traction therapy

Surgery
Surgery is performed in three approaches:

• Surgery to cut down the part of the penis that is opposite to the plaque or curvature
• Surgery to elongate the part of the penis that is curved
• Surgery to place penile prosthesis in complex cases

The Nesbit operation may be performed by extremely specialized urological surgeons who are skilled in techniques used for corrective surgeries.
The Leriche technique uses an 18 gauge needle to cut the plaque. It is known to be effective in decreasing the curve and providing sexual function.